We develop and validate methods for organizing, summarizing and visualizing complex biological data for systems biology through the integration of bioinformatics and biostatistics.
Data sets collected for pan-cancer cell lines (mutation, methylation, copy number aberration (CNA), cancer type, gene-expression, proteomics and IC50 (drug response)) were topologically ordered. There is no direct relation between mutation, methylation, CNA, cancer type with IC50; all this information is channeled through the gene-expression. Proteomics does have a separate link with IC50 due to PTMs. Find out more here.
As of April 1, Age Smilde is Editor-in-Chief of the Journal of Chemometrics. He will be responsible - together with the editors and the editorial board members - for the scientific content of the Journal.
As of November 2017, Age Smilde is a member of the Editorial Advisory Board of Metabolites.
The paper entitled Covariances Simultaneous Component Analysis: a new method within a framework for modeling covariances, authored by Age K. Smilde, Marieke E. Timmerman, Edoardo Saccenti, Jeroen J. Jansen and Huub C. J. Hoefsloot, J. Chemom., 2015, volume 29, pages 277-288, has been selected as the winner of the 2017 Kowalski prize for the "Best Application Paper" published in the Journal of Chemometrics in 2015 and 2016.