Info
Huub C.J. Hoefsloot
Work address:
Group Biosystems Data Analysis, University of Amsterdam
Science Park 904, 1098 XH, Amsterdam
Phone +31 20 525 5867
Email: h.c.j.hoefsloot@uva.nl
Websites:
www.bdagroup.nl; www.uva.nl/profiel/h/o/h.c.j.hoefsloot/h.c.j.hoefsloot.html
Professional Career
Huub C.J. Hoefsloot holds an MSc in Mathematics (1987) and a PhD in Chemical Engineering / Numerical Mathematics (1992). In 1991, he started as an assistant professor at the Universiteit van Amsterdam. In 2000 he became associate professor and in 2001 he joined the Biosystems Data Analysis group (SILS). From 2012-2021 he was the director of the MSc life science: bioinformatics & systems biology, for one day per week. He teaches in several courses at both master and bachelor level. He acted as daily supervisor for more than 25 PhD’s and Post-Docs and he supervised many Master and Bachelor students. He has published more than 150 peer-reviewed papers on simulations and data analysis in the fields of chemistry, physics, engineering, life sciences and education.
Research
His main research area is building and validating (dynamical) models of complex biological/chemical processes. The aim of this research line is to better understand the dynamical behavior of biological systems. This research is on the interface of mathematics, computational science, and computational biology. The methods used are commonly in the form of sets of differential equations, agent-based models or combinations thereof. With these tools both the dynamical behavior of molecular networks and cellular interactions can be simulated. These simulations should have a predictive value and experimental data and experts’ knowledge should be incorporated when building the models. Examples of systems that are currently studied in this line are: optimal measurement protocols for enzyme kinetics (NWO-TA Moonlight, together with Jesse Alderliesten) models of glucosinulate pathways in plants(NWO-LTP Plant-XR, together with Jordan Earl), agent based model for the germinal centre (in cooperation with AUMC group van Kampen) and the interaction of the microbiome and the immune system in young infants (NWA-ORC METAHEALTH together with Shivam Kumar).
Courses and topics
MSc Biomedical Sciences
Biomedical Systems Biology: Modelling with COPASI.
Molecular Biology of the Cell: Presentations.
BSc Medical Biology
Frontiers in medical biology I: Computational models.
Frontiers in medical biology II: Pitch.
Humane Fysiologie: Models.
BSc beta gamma
Van de oerknal tot het leven: Glucose insuline laptop prakticum.
BSc Biomedische Wetenschappen
OMICS in de biomedische wetenschappen: Systeem biologie.